There currently are a variety of options to travel by night bus or night train from Brussels (Belgium) to Prague (Czech Republic), taking between approximately 12 and 17 hours: Namely the BUS Londýn - Praha and the ES 453. These lines are operated by Regiojet and European Sleeper.

Next offers

Regiojet operates both night trains and night buses across Europe, providing various travel options. Their night trains feature several types of cabins, including seats that can recline slightly for added comfort, as well as private sleeping couchettes that accommodate one to four passengers, equipped with bedding and duvets. Wifi is available and breakfast and coffee are complimentary. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.

European Sleeper is a young Dutch startup connecting several European cities in Belgium, the Netherlands, Germany and the Czech Republic with their "Good Night Train". In the sleeper cars, you can book lockable single, double or triple compartments, all with their own washbasin. Bedding, toiletries, towels and breakfast are included. Compartments can be locked from the inside. The couchette cars come in two variants: standard (6 people) and comfort (5 people, air-conditioned). Both include bedding, blankets and pillows. Comfort compartments can be booked as private or women-only compartments. The compartments can be locked from the inside. The seating cars offer, as the most affordable travel option, 6-person compartments with guaranteed seat reservations. Breakfast can be booked for an additional fee, drinks and snacks are available on board.

For the next 7 dates with connections, the cheapest offer starts at 50 EUR. Check our connection pages below for all availabilities!

Next available offers

Mon, 28.07.2025

offers

Wed, 30.07.2025

offers

Fri, 01.08.2025

from 260 EUR

Sun, 03.08.2025

from 73 EUR

Mon, 04.08.2025

from 160 EUR

Wed, 06.08.2025

from 140 EUR

Thu, 07.08.2025

from 50 EUR